Lowestoft broke Bury Town hearts with a 93rd minute winner after the home side battled bravely after being reduced to nine men.
In an explosive opening Bury took the lead in the 2nd minute with a fine curling shot into the top corner by Sam Reed from 20 yards.
John Sands then came close to adding a second from a free kick inside the box.
At the other end Marcus Garnham made a brilliant save to deny Chris Henderson and Matt Nolan went close with a shot across the face of goal.
The pivotal moment of the game came on 22 minutes when Tom Bullard fouled Nolan in the box and was sent off. Dean Sinclair scored from the resultant penalty kick.
Bury came back well after that setback and Andy Reynolds made a brilliant flying save from John Kennedy`s 20 yard pile driver.
Bury regained the lead on 29 minutes when Sam Nunn rose to head home from Sam Reed`s cross.
Lowestoft came back strongly and forced several corners but failed to trouble Garnham until the closing minutes when Lubo Guentchev forced a fine save from the keeper.
Half Time: Bury Town 2 Lowestoft Town 1
The second period started with the visitors on top and they duly equalised on 51 minutes. Bury failed to deal effectively with a corner and Sam Gaughran hooked the ball home from close range
Lowestoft were having the bulk of possession and little was seen of the Bury attack.
Garnham was by far the busier keeper and made great saves from a Nathan Stone header and two more from Scott Mitchell as Lowestoft poured forward.
On 83 minutes Bury were reduced to nine men when Danny Cunningham was sent off for a rash challenge on Mitchell, and the Bury goal then came under siege
Nathan Stone had a close range effort disallowed for offside in the dying minutes, but Lowestoft were not to be denied, and with three minutes of the allotted extra four gone, Guentchev headed home the winner.
Full Time: Bury Town 2 Lowestoft Town 3